Kuhn was born in Germantown, Province of Pennsylvania, a son of German immigrant parents.
in June 1767, and published his thesis, De Lavatione frigida ('About cold baths').
[1] Returning to America, he practiced as a physician in Philadelphia and was 1768–1789 professor of Materia medica and 1789–1797 of the Theory and Practice of Medicine at the Medical School of the College of Philadelphia (later the University of Pennsylvania), founded in 1765 as the first faculty of Medicine in the thirteen colonies.
[1] His students included Valentine Seaman, who mapped yellow fever mortality patterns in New York and introduced the smallpox vaccine to the United States in 1799.
[4] Benjamin Rush wrote in his autobiography that Kuhn, after the death of Dr John Jones in June 1791, was considered the leading physician in Philadelphia and the one favored by "the principal officers of the general government".