Adipokinetic hormones (AKHs) are metabolic neuropeptides, mediating mobilization of energy substrates in many insects.
[citation needed] The typical makeup of hormones in this family includes a length between 8 and 10 amino acids, blocked N and C termini, with phenylalanine or tyrosine at position 4.
[8][9] The spread of malaria by the female mosquito, Anopheles gambiae, is partly dependent on the adipokinetic hormone, Anoga-HrTH (pGlu-Leu-Thr-Phe-Thr-Pro-Ala-Trp-NH2).
The NMR restrained molecular dynamic was used to investigate its conformational space in aqueous solution and when bound to a membrane surface.
Information about the 3D structure and binding mode of Anoga-HrTH to its receptor are vital for the design of suitable mimetics which can act as insecticides.