5710466853ENSG00000177666ENSMUSG00000025509Q96AD5Q8BJ56NM_020376NM_001163689NM_025802NP_065109NP_001157161NP_080078Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the PNPLA2 gene.

[11] Defects in ATGL can cause problems in lipolysis, leading to neutral lipid storage disease.

Because adipose tissue triglyceride is a major form of energy storage, the study of how ATGL regulation and dysregulation can lead to potential problems will increase understanding of the pathophysiology behind metabolic disorders.

Lipolytic breakdown performed by ATGL would impact regulatory functions including but not limited to cell death, growth, signaling, metabolism, and gene expression.

[13] Adipose Triglyceride Lipase (ATGL) can undergo activation through two different pathways: transcriptionally and through post-translational modification.