The Parliament of New South Wales passed an Act to incorporate Prince Alfred Hospital on 3 April 1873 and appointed Mansfield Brothers as architects.

The major public spaces were redecorated c. 1986 as part of the alterations made in building E block; the architects for this work were McConnell, Smith and Johnson P/L.

Together with the Victoria & Albert Pavilions, the group has an important landmark quality as one of the most imposing facades in Sydney.

[2][1] Admission Block, Royal Prince Alfred Hospital was listed on the New South Wales State Heritage Register on 2 April 1999 having satisfied the following criteria.

In order to help develop an ethic of "self-help" amongst the working classes all patients were encouraged to pay an appropriate level of fee.

[1] The system of tickets of admissions to hospitals gradually vanished, with the majority of the funding now being provided by the government rather than by public subscription.

[3][1] The place is important in demonstrating aesthetic characteristics and/or a high degree of creative or technical achievement in New South Wales.

[1] The original hospital buildings were designed according to the latest known techniques, and include the use of steel beams with small span concrete or corrugated iron vaulting between.

[1] In addition the layout was designed to provide for the movement of patients around the hospital, on trolleys before the widespread use of lifts.

[1] Hospitals are places of major events in the lives of individuals in the community, births, serious illnesses, accidents and deaths.

[1] The staff, both the doctors and the nurses have strong associations with the place, particularly because of the length of time many spent within the institution as a student.

[3][1] This Wikipedia article was originally based on Royal Prince Alfred Hospital - Admission Block, entry number 830 in the New South Wales State Heritage Register published by the State of New South Wales (Department of Planning and Environment) 2018 under CC-BY 4.0 licence, accessed on 13 October 2018.