She played Dorothy Gale in the Oz book adaptation Emerald City (2017), Anathema Device in Good Omens (2019), and Bix Caleen in Andor (2022).

She has starred in Father of the Bride (2022), Hit Man (2023), and Blink Twice (2024) with supporting roles in Pacific Rim Uprising (2018), Life of the Party (2018), Triple Frontier (2019), 6 Underground (2019) and Morbius (2022).

[10] In December 2018, she entered negotiations in the Sony spinoff Morbius to portray the film's female lead Martine Bancroft, and her involvement was confirmed at the end of January.

[12] In a review of the picture, David Rooney of The Hollywood Reporter wrote: "Arjona carries herself with confidence, but her character also gets a little lost in the carnage".

She joined previously announced series lead Diego Luna, who reprised his role from the 2016 film Rogue One: A Star Wars Story.

[18] In October 2021, Arjona starred in and executive-produce the drama film Los Frikis, written and directed by Tyler Nilson and Michael Schwartz.