The film features Robert De Niro, Ben Stiller, Owen Wilson, Blythe Danner, Teri Polo, Dustin Hoffman, Barbra Streisand, and Thomas McCarthy reprising their roles from previous films, with Jessica Alba, Laura Dern, Kevin Hart and Harvey Keitel joining the cast.

Five years after the events of the previous film, Greg Focker and his wife Pam are preparing to celebrate the fifth birthday of their twins Samantha and Henry.

Recently, Jack has been diagnosed with a heart condition and has become embittered by his daughter Debbie's divorce from her husband Bob — their marriage was the social event of the first film, and how he and Greg met — for cheating on her with a nurse.

Jack's original plan was to declare Bob his successor, but he decides to pass the role to Greg, naming him "The Godfocker".

The presence of Sustengo, an erectile dysfunction drug that Greg promotes as a side job, also prompts Jack to think he is no longer sexually attracted to Pam.

During a medical conference promoting Sustengo, Greg meets Bob at a bar, and he tells him of Jack's original intention to name him "The Bobfather" as his successor.

Eventually, following a confrontation with Jack at a clinic, Greg escapes to his and Pam's unfinished new house, where Andi shows up.

She tries to cheer him up with Chinese food and wine but drinks too much and makes an extremely aggressive sexual advance on Greg after taking too many Sustengo pills.

[2][3] Writer John Hamburg stated that the film would deal with "themes of death and divorce and all these real things that, as we get older, we start to think about, but in a really comical way".

[4] Outside the United States, it is the first film in the series to be released by Paramount Pictures, whose 2006 acquisition of the DreamWorks back-catalog included co-ownership of and sequel rights to the Meet the Parents franchise.

The site's critical consensus reads, "As star-studded as it is heartbreakingly lazy, Little Fockers takes the top-grossing trilogy to embarrassing new lows.