[13][14] Wilson joined the debating team and a teacher encouraged her to enter Tournament of Minds, which she credits for helping her come out of her shell.

Wilson worked at a cinema in Castle Hill in her younger years, but quit after patrons recognised her after the showing of her first movie, Fat Pizza.

[18] Wilson stood by this belief in court, despite there being no evidence to support the claim;[19][20] it continues to be disputed by genealogist Dale Sheridan.

[29] Her follow-up stage productions, which she wrote, produced and starred in include Spunks and Confessions of an Exchange Student.

[35] Not content with her small role in Ghost Rider, Wilson moved to the United States in January 2010 and signed to talent and literary agents William Morris Endeavor.

[38] She co-hosted the 2010 ARIA Music Awards and performed at the inaugural Variety's Power of Comedy event in Los Angeles with Lucas and Russell Brand.

[42] In 2012, Wilson voiced a character in Ice Age: Continental Drift[42] and played Fat Amy in Pitch Perfect.

[37] Wilson joined the voice cast for Kung Fu Panda 3;[57] however, in September 2015, she was replaced with Kate Hudson.

[59] Nigel M. Smith of The Guardian wrote, "Wilson is the standout, nailing every pratfall she's dealt, but How to Be Single doesn't make strong use of her character.

[64] She made her West End debut in the musical Guys and Dolls in the role of Miss Adelaide from 28 June to 21 August 2016.

[70][71] In May, Wilson starred alongside Anne Hathaway in The Hustle, a female-centred remake of the 1988 comedy film Dirty Rotten Scoundrels.

[66][72] Wilson plays twins Doreen and Dolores Bognor in Australian drama series Les Norton.

[73] Towards the end of 2019, Wilson played Fraulein Rahm in Taika Waititi's dark comedy drama Jojo Rabbit,[74] and Jennyanydots in the musical film Cats.

She plays a woman who, after waking from a 20-year coma, returns to high school to earn the prom queen crown she feels she deserves.

[78] Wilson will appear in her first non-comedy film role in The Almond and the Seahorse, which is an adaptation of Kaite O'Reilly's stage play of the same name.

[79] Wilson is making her directorial debut with The Deb, a musical comedy film set in the Australian outback.

[80] In 2013, Wilson created a plus-size T-shirt collection named after her "Fat Mandi" character in The Wedge featuring images of donuts and cupcakes.

[82] Wilson and her Bridesmaids co-star, British actor Matt Lucas, lived together in West Hollywood,[83] from September 2012 until 2015.

[91] As her 40th birthday approached, Wilson made the decision to freeze her eggs, which spurred on her effort to make healthy life changes.

"[94] She chose to announce her relationship with Agruma to pre-empt an article by Andrew Hornery of The Sydney Morning Herald that would have outed her.

[108] Wilson asserted that the producers of Pitch Perfect had refused to let her lose any more weight during filming, as her contract stated that she must stay the same size.

[109] In May 2015, Australian magazine Woman's Day published a story claiming that Wilson had been misleading about her birth name, age, and upbringing.

[110] Wilson had previously said in interviews that she was raised by dog-training "bogan" parents in the ghetto of Sydney, spent a year in Zimbabwe, climbed into a cage with a leopard, got caught in a shoot-out and then struck down by a severe strain of malaria from a mosquito in Mozambique where, from her intensive care bed, she envisioned herself winning an Oscar and rapping her acceptance speech.

[19] Woman's Day called all of this into question and claimed that Wilson had, on the contrary, a "very normal, upper-middle-class upbringing" and "added a touch of 'fantasy' to the life she led before becoming a household name".

[110] The story was picked up by several other publications including The Sydney Morning Herald, People magazine,[112] the Chicago Tribune[113] and The Huffington Post.

Following the appeal, Wilson continued to stand by her claim that she is related to Walt Disney by marriage, despite having no evidence to support this.

[118][119][120][121] It garnered attention for her recounting of discomfort on the set of The Brothers Grimsby, including Sacha Baron Cohen's alleged requests for nudity and inappropriate behavior during a sex scene, which she refused.

[122] Following this episode, publication was pushed back and significant portions of the chapter associated with this incident were redacted for the UK due to legislation regarding factual accuracy and libel.

According to a defamation writ filed in the Supreme Court of Victoria, Wilson said her reputation and credit had suffered and she had been humiliated and embarrassed.

In June 2017, Wilson tweeted "Any dollars I receive will go to charity, scholarships or invested into the Aussie film industry to provide jobs.