[6] Under the leadership of Mother Gerald, the Congregation achieved pontifical status in 1944 and extended its ministries overseas — to the Dominican Republic, Puerto Rico, and Peru.

In 1959, as the Congregation grew in numbers, it was divided into five provinces with headquarters in Detroit, Michigan (2), Chicago, Illinois, West Palm Beach, Florida, and Santa Cruz, California.

Over the years, Sisters Nadine Foley and Donna Markham were elected president of the Leadership Conference of Women Religious in the United States during their terms as Prioress.

Sisters Nadine Foley and Patricia Walter have represented United States women religious on the Council of the International Union of Superiors General.

Sister Nadine Foley also wrote chapter 15 of Transforming the Faiths of our Fathers: Women who Changed American Religion (2004), edited by Ann Braude.

[10] Acting upon the directives sent from Rome after Vatican Council II, the Congregation developed new Constitutions that received approval on April 29, 1989.

In a coming around full circle, the community in the Philippines that got its start in partnership with the Adrian Dominican Sisters decided to merge with the Congregation.

[13] The Chapter delegates also approved four Enactments that they will focus on through General Chapter 2022: deepening their spirituality and engaging with others in prayer and presence; sacrificing to mitigate their impact on climate change and ecological devastation; facilitating and participating in resilient communities with people who are relegated to the margins;[14] and deepening their relationships with one another, inviting others to vowed and Associate life, and expanding collaboration.

[16][17][18] As of January 2021, the Congregation has 507 Sisters and 215 lay Associates, who minister throughout the United States as well as in the Dominican Republic, Norway, and the Philippines.

[19] The Adrian Dominican Sisters led shareholder activism efforts, including in the areas of executive compensation, climate change, the rights of indigenous peoples, and gun control.

The Adrian Dominican Sisters introduced shareholder resolutions asking firearms manufacturers American Outdoor Brands Corporation (the parent company of Smith & Wesson) and Sturm, Ruger & Co. and retailer Dick's Sporting Goods to report to investors regarding the steps they are taking to reduce gun violence.

[20][21][22][23][24] The Adrian Dominican Sisters purchased 200 shares of American Outdoor Brands Corporation (AOBC), the minimum holding needed to qualify to formally submit shareholder resolutions.

"[25][26][27][28][29][30] The Adrian Dominican Sisters purchased $2000 worth of shares of Sturm, Ruger & Co. in order to qualify to formally submit shareholder resolutions.

"[21][31][32][33][34][35][36][37][38][39] The Adrian Dominican Sisters were among shareholders that helped influence retailer Dick's Sporting Goods to stop selling AR-15 style rifles at its Field & Stream stores.