[6] Broner turned professional on May 31, 2008, and scored three consecutive first-round knockouts against Allante Davis, David Warren Huffman and Ramon Flores.

In January 2009, he was forced to go the distance with Jose Alfredo Lugo, at the Staples Center on the undercard of Shane Mosley vs Antonio Margarito.

On the Juan Díaz vs Paul Malignaggi undercard in Houston Broner made short work of Edgar Portillo, victory coming via stoppage in the first round.

Broner defeated Henry White Jr via KO in September and finished his busy year against Tommy Atencio.

In 2010, Broner engaged in four more fights with Rafael Lora, Carlos Claudio, Guillermo Sanchez, and Ilido Julio, stopping them all.

Broner took his first major step up in weight when he competed against former Super Bantamweight champion Daniel Ponce de León on March 5, 2011.

Broner slowed down in the middle and later rounds, though landed the cleaner shots, while De Leon proved to be the busier fighter.

Broner made a successful first defense of his WBO belt against Top 10 Super Featherweight contender and mandatory challenger Eloy Pérez on a February 25, 2012, HBO-televised card.

Broner's next scheduled fight was to be on July 21, 2012, at the U.S. Bank Arena in Cincinnati, against Super Featherweight contender Vicente Escobedo.

However, at weigh-in for the fight on July 20, Broner was 133+1⁄2 pounds, well over the 130-pound limit for the Super Featherweight class, and was automatically stripped of his title.

DeMarco's corner stopped the fight right after the knockdown, giving Broner his second world title in as many weight classes.

The fight was announced in December 2012, with many believing it to be a mismatch, to take place at Boardwalk Hall in Atlantic City, New Jersey.

[23] The fight was due to take place at the MGM Grand Garden Arena, but later moved to the Alamodome in San Antonio.

[33] On March 26, 2014, it was announced that Broner would mark his first professional fight as a light welterweight on the Mayweather vs. Maidana undercard on May 3 at the MGM Grand Garden Arena against once beaten fringe contender Carlos Molina (17-1-1, 7 KO), who had not fought since being handed his first professional loss to Amir Khan in December 2012.

[39][40] Broner remained at light welterweight to fight 23 year old Emmanuel Taylor (18–2, 12 KOs) for the WBA International title.

Broner spent a large portion of the early rounds on the ropes, appearing to be unaffected by Taylor's punches.

[44][45] On May 16, 2015, TGB Promotions and Mayweather Promotions announced that Broner would fight fellow Ohio boxer and former IBF Welterweight champion Shawn Porter (25-1-1, 16 KOs) on June 20 at the MGM Grand Grand Garden Arena in Las Vegas on Premier Boxing Champions on NBC at a catchweight of 144lbs as per Broner's demand.

[53] On August 28, Showtime announced via an official press release the fight was confirmed for October 3 at the U.S. Bank Arena in Cincinnati, Ohio.

[56][57][58] On February 19, 2016, Premier Boxing Champions announced that Broner would defend his WBA light welterweight title against British veteran boxer Ashley Theophane (39–6–1, 11 KO) on April 1 at D.C. Armory in Washington, D.C., live on Spike.

[69] On February 9, 2017, it was revealed that the fight would take place at the welterweight limit of 147 pounds after a request from Broner when he felt sick during training camp.

[76] On May 25, 2017, it was announced that talks were underway for a fight between Broner and WBC lightweight champion Mikey Garcia (36–0, 30 KOs) on July 29, 2017, at Barclays Center in Brooklyn.

On Monday 22 May, Broner was sentenced to 72 hours at the Kenton County Detention Center in Covington, Kentucky, on a contempt charge, after failing to make multiple court appearances.

[88] On November 5, 2017, according to Alex Vaysfeld, manager of IBF light welterweight champion Sergey Lipinets (13–0, 10 KOs), Broner was being targeted as a first defence for March 2018.

[89] On December 18, The Ring TV reported that a deal was being discussed which would match Broner against Omar Figueroa Jr. (27-0-1, 19 KOs) on Showtime in the Spring of 2018.

[99] After eight-division world champion Manny Pacquiao signed with Al Haymon in October 2018, reports circulated that Broner was the front-runner to face him in January 2019.

[101] On November 19, 2018, a press conference was held in New York City to confirm the fight between Broner and Pacquiao on January 19, 2019, for the WBA (Regular) welterweight title.

The fight took place at the MGM Grand Garden Arena in Las Vegas, Nevada and was distributed by Showtime PPV.

In contrast, Broner was reluctant to throw combinations, and typically stuck to singular jabs and worked with his back to the ropes.

[121] On September 10, 2017, TMZ reported an incident in Las Vegas that was caught on video of Broner knocking out an agitating fan.

"[123] On February 13, 2018, Broner was booked into Fulton County Jail in Atlanta on a misdemeanor sexual battery charge but was later released on bail.