On April 24, 2010[2] in the HBO undercard of Chris Arreola vs Tomasz Adamek, Molina beat veteran Jose Antonio Izquierdo by second round K.O.
[5] In May 2011, John stopped the tough veteran Alejandro Rodríguez to win the vacant WBC USNBC Lightweight Championship with his next fight was a T.K.O.
[6][7] After knocking out Dannie Williams in another Friday Night Fights appearance in January 2013, Molina would lose to an undefeated Andrey Klimov by majority decision in June 2013.
[8] After the Klimov loss, Molina fought unbeaten Cleveland lightweight Mickey Bey on the main event of a Mayweather Promotions card broadcast on ShoBox from Hard Rock Casino in Las Vegas on Friday, July 19, 2013.
[9] Molina was defeated by Adrien Broner via unanimous decision in the first episode of the Premier Boxing Champions series of fights on NBC.
On December 10, 2016, Molina Jr fought Terence Crawford for the WBC, WBO and The Ring light welterweight titles.