[10] The yellow buckeye is most successful in full sun in moist, rich, well-drained, seep and slightly acidic soils.

The seed is very rich in saponins which are poisonous and are poorly absorbed in the human body, but can pass through without harm.

[17] Eating large portions of food that contain saponins is not a good idea, poisoning is rare but abdominal pain is possible.

[18] The largest of the buckeyes, the Native Americans historically made food from the seeds, after the removal of the toxic element by roasting and soaking.

[19] The seed contains saponins and needs to be leached of toxins before it can be eaten, the North American Indians would do so by slow-roasting the nuts, cut them into thin slices, put them in a cloth bag to be rinsed in the stream for 2-3 days.

Pests of this plant include the buckeye lacebug, Japanese beetles, bagworms, and borers, these are rare but can be troublesome.

Aesculus flava tends to produce large amounts of leaf and flower litter in the summer and fall.

The fruit makes good food for wildlife but can produce undesirable litter in urban areas.

[27] Saponins can be obtained by chopping them up into small pieces immersing them into hot water, it can be used to wash the body or clothes.

The tree's showy yellow flowers and good autumn color are attractive in larger gardens and in parks.