[3][4] After finishing high school in Poland,[5] Smogorzewska completed her bachelor of science in molecular biology and biochemistry in 1995 at the University of Southern California.
[3][4][5] Smogorzewska then went on to a residency in clinical pathology at the Massachusetts General Hospital from 2003 to 2006, becoming a postdoctoral researcher at Harvard Medical School between 2005 and 2009 under Dr. Stephen Elledge where she discovered the Fanconi anemia protein FANCI.
[3][4] To this end, Smogorzewska has successfully identified SLX4, RAD51 and UBE2T as interstrand crosslink repair factors, as well as developed a mouse model of karyomegalic interstitial nephritis.
[3] Recently, Smogorzewska has begun studies revolving around how replication stress is addressed by cells to promote genome stability.
[4] Smogorzewska is a part of the American Society for Biochemistry and Molecular Biology,[6] the New York Academy of Sciences,[7] the American Society of Clinical Investigation[8] and the American Society of Human Genetics[9] [3][5] Regulation of telomerase by telomeric proteins – Annual Review of Biochemistry, 2004 Control of human telomere length by TRF1 and TRF2 – Molecular and Cellular Biology 2000 Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair – Cell, 2007 Different telomere damage signaling pathways in human and mouse cells – The EMBO Journal, 2002 Fanconi anaemia and the repair of Watson and Crick DNA crosslinks – Nature, 2013 DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2 – Current Biology, 2002 A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair – Molecular Cell 2010