Agave sileri (synonym Manfreda sileri)[1] is a species of Agave known only from coastal areas in the States of Texas and Tamaulipas.

It grows on open locations with clay soil, at elevations below 100 m (330 feet).

[3] Agave sileri is a perennial herb spreading by means of globose underground rhizomes.

It produces rosettes of waxy, light green leaves mottled with dark green or brown spots.

The flowering stalk can reach a height of up to 220 cm (7.2 feet), with as many as 80 greenish-yellow flowers bearing large yellow anthers.