Agios Germanos, (Greek: Άγιος Γερμανός), is a village in the Prespes Municipality in West Macedonia, Greece.

Agios Germanos is located at an altitude of approximately 1,040 m (3,410 ft), on a hillside, part of the Varnous Mountains.

The Byzantine church that forms the nucleus of the present village dates to the beginning of the 11th century.

The village is especially known among tourists for hiking, bird watching and the Agios Germanos river with falls, which has the endangered species of Prespa trout.

Following the paths, one can reach the impressive mixed fir-beech forests, and the summits of Kitsevo or Despotiko (2,177m).

The Sarakatsani, nomadic shepherds from Thessaly, have the tradition of bringing their herds to graze on these mountains every year from May to October.

A separate neighbourhood of the village named Shaoftsi (Macedonian: Шаофци) was inhabited by Muslims and later repopulated by Greek refugees.