Vasari considered him a pupil of the painter and architect Bernardino Zenale, stressing the pictorial quality of his work.
The earliest work usually attributed to him is a marble monument in 1513 for the funeral of the Milanese poet and humanist Lancino Curzio.
It was modeled on a funeral stele, and included allegorical and mythological figures but no religious reference.
Begun no later than 1517, the project was never completed due to the political difficulties of the city's rulers, who abandoned Milan in 1522.
Busti worked on a number of tombs and monuments in his life including those of Gian Marco, Zenone Birago, Mercurio Bua, Giovanni Antonio Bellotti, Marino Caracciolo, Canon Giovanni Vimercati, and Saint Evasius.