He initially copied prints by Albrecht Dürer and Giulio Campagnola from about 1512-14, and then producing his own works, somewhat in the style of the latter.
Unlike many produced by the workshop, most of Agostino's plates avoided being confiscated and melted down by Charles V's soldiers, and continued to be printed in later years.
He was the only major figure whose career spanned the whole period which saw the birth of the reproductive print, and the beginnings of the "industrialization" of Italian printmaking.
His print known as The Climbers (1521) records a part of a cartoon drawing by Michelangelo for a large painting of the Battle of Cascina for the Palazzo Vecchio in Florence, never completed.
[6] His career probably never entirely recovered from the Sack of Rome; in Venice his illustrations for Serlio were not used, though he continued to produce prints after Raphael, Giulio Romano and others in his later years, sometimes doing new versions of his older works.