She is best known for her roles in several telenovelas including Tayong Dalawa, Tanging Yaman, Nasaan Ka, Elisa?, FPJ's Ang Probinsyano, and Can't Buy Me Love.
Isidro started as a back-up singer alongside her sisters Olive Cruz and Tina Isorena in The Sharon Cuneta Show.
She was urged by Johnny Manahan or Mr. M to fill-in for then pregnant Melissa de Leon in the noontime show 'Sang Linggo nAPO Sila.
She is fourth among six children of Jose Isidro, an architect, and Palestinian mother Edwarta Fteha, and is their youngest daughter.
Isidro continued to rise as a talent and was given numerous projects including recording albums, movies, television, and theater.
Isidro made her theatrical debut in August 2003 with Honk!, a musical inspired by Hans Christian Andersen's "The Ugly Duckling."