[7] Additionally, at the age of 28, she is one of the youngest recipients of the Bert Marcelo Lifetime Achievement Award from the Guillermo Mendoza Memorial Scholarship Foundation for her contributions to Philippine industry.

She also starred in horror films like: White Lady, Bulong, and Segunda Mano where she was recognized as Best Supporting Actress in the FAMAS Awards.

Her notable appearances include Jenny in the 1993 Maricel Soriano drama movie, Separada where she won two Best Child Actress awards in the FAMAS and PMPC Star Awards; and Becky in the 1995 family-drama film, Sarah... Ang Munting Prinsesa with her friend, Camille Prats in the title role where she received Best Child Actress nominations.

In 2001, Panganiban played the role of Paula Villamines in the drama series, Sa Puso Ko Iingatan Ka which was top-billed by Judy Ann Santos.

In 2002, she portrayed the role, Nicole in another youth-oriented show entitled, Berks along with her love team partner, Carlo Aquino.

She appeared as the girlfriend of Aquino's character in the hit comedy film, Ang Tanging Ina top-billed by Ai-Ai de las Alas in 2003.

In the same year, Panganiban appeared in the film, A Love Story with Aga Muhlach and Maricel Soriano from which she earned her first Best Supporting Actress trophy in the FAP Luna Awards.

[19] She also appeared in Judy Ann Santos' romantic soap opera, Ysabella as a guest character, and in December 2007, she played Lena in Maging Sino Ka Man: Ang Pagbabalik with Derek Ramsay, Toni Gonzaga, and the original cast: John Lloyd Cruz, Bea Alonzo, Sam Milby, and Anne Curtis.

She became a full-fledged adult dramatic actress in the 2008 primetime drama series, Iisa Pa Lamang with Claudine Barretto.

[24] The following year, Panganiban starred in Here Comes The Bride, a 2010 comedy film with Eugene Domingo, Tuesday Vargas, Jaime Fabregas, Tom Rodriguez, and John Lapus.

On February 11, 2013 marked her comeback in Philippine Primetime via television drama, Apoy Sa Dagat alongside Piolo Pascual and Diether Ocampo.

It was Panganiban's first time to play a dual role in the series and first in the history of Philippine TV to have billed the lead star twice.

[33] She also received an Achievement in Acting nomination in the 2015 Guam International Film Festival for her exceptional performance as Mace Castillo in the said movie.

[34] Panganiban played the iconic character of Madam Claudia Buenavista, originally portrayed by Jean Garcia, in the 2015 remake of Pangako Sa ’Yo.

[36] On July 17, 2020, it was announced that Panganiban is joining the series on the upcoming Kapamilya Channel's Walang Hanggang Paalam, after Julia Montes and Nadine Lustre are backed out.

[37] She also announced that Walang Hanggang Paalam will be her last drama show as she will retire from teleseryes but clarified that she would not leave ABS-CBN and acting altogether.

[40] In November 2010, she was reunited with Charlson in Los Angeles, California after 24 years apart, when ABS-CBN gave her a week-long break from work.

[42] On December 31, 2023, she married Gregg Homan in a small rooftop wedding in Los Angeles, which was witnessed by chosen family members and close friends including Kim Chiu, Bela Padilla and their daughter Amila Sabine.

On April 20, 2024, in the second wedding ceremony in Siargao, Glaiza de Castro was chosen a bridesmaid, while Amila Sabine "Baby Bean" was the flower girl.