He has previously played in Nippon Professional Baseball (NPB) for the Tohoku Rakuten Golden Eagles.

Murillo was signed by the Arizona Diamondbacks as an undrafted free agent in 2002 for the baseball legend Jack Pierce.

At the time, Murillo had a career .275/.344/.399 batting line with 36 home runs and 236 RBI in 514 minor league games.

[6] On September 27, 2021, Murillo, along with IF Amadeo Zazueta and P Nick Struck, were traded to the Toros de Tijuana of the Mexican League.

[7] On December 30, 2022, Murillo was traded to the Rieleros de Aguascalientes of the Mexican League in exchange for IF Marc Flores.

[11] However, on November 8, Murillo was traded to the Tigres de Quintana Roo in exchange for Javier Erro.