[4] After rehabbing, Campillo made a rocky first post-surgery appearance with the Mariners in late 2006, after the team purchased his contract from Triple-A Tacoma.

Campillo played Winter Ball prior to the 2007 season, when he very successfully headlined the Triple-A Tacoma Rainiers' starting rotation.

After the end of the minor league season, he was recalled to Seattle, where Campillo made several successful appearances out of the Mariner bullpen.

On December 17, 2007, Campillo signed with the Atlanta Braves to a minor league contract with an invitation to spring training.

On March 17, 2011, Campillo signed with the Tigres de Quintana Roo of the Mexican League in 20 games (17 starts) he threw 80.2 innings going 3-7 with a 5.58 ERA with 47 strikeouts and 1 save.