Following his initial medical training, Shafik joined Cairo University's Faculty of Medicine, where he held various academic and clinical positions, culminating in his appointment as Professor and Chairman of the Department of Surgery and Experimental Research in 1990.

[5] In 2016, he was awarded the Ig Nobel Prize for his unique study on the effects of different textiles (polyester, cotton, and wool trousers) on the sexual activity of rats.

[5] His research demonstrated that polyester-induced static electricity could negatively impact reproductive health, providing insights into how fabric types might influence human physiology as well.

These discoveries underscored his ability to bridge clinical insights with foundational physiological research, sparking discussions within the scientific community despite limited replication efforts.

[1] His commitment to experimental and clinical studies laid the groundwork for a deeper understanding of colorectal and urinary tract diseases, as well as the impact of external factors on physiological health.

For instance, research into the role of the levator ani muscle during defecation has provided additional insights into the complex interactions within the pelvic floor musculature, building on Shafik's foundational work.

[13] Shafik's extensive research portfolio includes over 1,000 peer-reviewed papers covering topics from pelvic floor reflexes to innovative surgical techniques.

[14] Shafik’s groundbreaking techniques in colorectal and pelvic floor surgery remain a cornerstone in contemporary medical practice, frequently referenced and adapted by modern surgeons.

Shafik's work continues to inspire a new generation of surgeons and researchers, encouraging a holistic approach to patient care and the exploration of uncharted scientific territories.