She has written for Big Mouth, Betty, and the HBO Max series Rap Sh!t, on which she also was an executive writer and star.

[4] Osman began working to build a following on Twitter in 2018 to attract the attention of casting agents and show runners.

[3] In 2022, Osman made her debut lead television role as a co-star and staff writer for Rap Sh!t (now canceled) on HBO Max.

In an interview with Teen Vogue, Osman noted, "I realized the nonbinary identity is just a helpful label for people who don't feel included in the normative divisions that our society has — woman and man, girl and boy.

In an interview with Teen Vogue, Osman noted that she no longer identified as Muslim, stating, "I've been all types of shit.