Aisha's paternal uncles included Umar Sheikh Mirza, the ruler of Ferghana Valley, who later became her father-in-law as well.
In her infancy, Aisha was betrothed to her double first cousin, Babur, the son of Umar Sheikh Mirza and her aunt, Qutlugh Nigar Khanum.
As Babur tells it, "Though I was not ill-disposed towards her [Aisha], yet, this being my first marriage, out of modesty and bashfulness, I used to see her once in ten, fifteen, twenty days.
[4] Thereafter, Aisha's aunt and mother-in-law, Qutlugh Nigar Khanum, used to scold him with great fury ("many dunnings" as he says in his autobiography, translated by Annette Beveridge) and send him to visit her every few days.
Babur states that his wife was misled by the machinations of her elder sister, Rabia Sultan Begum, who induced her to leave his house.