His family emigrated to South Africa in 1992 after his father, Kole Omotoso, took an academic appointment with the University of the Western Cape.

In 2010, he began working on Tell Me Sweet Something; speaking about the script with Pulse Nigeria, he stated that Theodore Witchers' Love Jones (1997) was the influence behind the film.

[4] In an interview with Azania Mosaka, he described the South African film industry atmosphere as having an enabling environment for aspiring filmmakers.

[5] In 2022, Omotoso directed Giannis Antetokounmpo biopic Rise for Disney, which received generally positive reviews.

Sourav Chakraborty of Sportskeeda found Rise to be an inspiring sports movie, stated Omotoso successfully provides an atmosphere of tension across his direction, and praised the performances of the cast members.