Akita Sanesue (秋田 実季, 1576 – January 11, 1660) was a Japanese daimyo who lived during the Azuchi–Momoyama and early Edo periods.
He was the son of daimyo Andō Chikasue, a powerful figure in Dewa Province.
Sanesue led his sons into combat at the Osaka Campaign in 1615.
In 1630, because of discontent against the shogunate, he was exiled to Asama in Ise Province, where he died in 1659.
Despite this exile, his son Toshisue survived, and was moved to the Miharu Domain, in Mutsu Province, where his descendants remained in power until the Meiji Restoration.