In the Kamakura period, they were installed in the Tsugaru district of Mutsu Province to trade with Ainu people for the Hōjō clan, and to administer Ezo as a penal colony.

Although his kokudaka remained unchanged 50,000 koku, Sanesue was very vocally unhappy with the transfer, and was eventually relieved of his position and exiled to Izu Province.

His son, Akita Toshisue was later transferred to Miharu Domain in Mutsu Province with an increase to 55,000 koku.

His son, Akita Morisue reduced the domain by 5,000 koku by giving a portion to his younger brother.

After the Meiji Restoration, the last daimyō of Miharu Domain, Akita Akisue, was given the title of viscount (shishaku).