Al-Busayrah (Arabic: الْبُصَيْرَة, romanized: al-Buṣayrah) is a town in eastern Syria, administratively part of the Deir ez-Zor Governorate.

The town is located, at the confluence of the Euphrates and Khabur Rivers, southeast of Deir ez-Zor.

Nearby localities include Muhassan to the northwest and al-Asharah, Mayadin and Hajin to the southeast.

During the Syrian Civil War, the city was part of the Islamic State of Iraq and the Levant until the Syrian Democratic Forces captured it on 12 November 2017, bringing it under the Autonomous Administration of North and East Syria.

On 6 August 2024, Syrian Army Backed Tribal Forces claimed to have captured the city amid an announced offensive in the region.