[6] In 593 AH/1196 CE, Muhammad ibn Abd al-Wahid al-Makhzumi al-Lubanni (d. 1260), a qadi (Islamic judge) in Baalbek, was born in the village.

They paid a fixed tax-rate of 33.3% on agricultural products, including wheat, barley, summer crops, olives, and goats or beehives; a total of 15,454 akçe.

Situated between Dayr Ghassāna in the south and the present Route 5 in the north, and between Majdal Yābā in the west and Jammā‘īn, Mardā and Kifl Ḥāris in the east, this area served, according to historian Roy Marom, "as a buffer zone between the political-economic-social units of the Jerusalem and the Nablus regions.

On the political level, it suffered from instability due to the migration of the Bedouin tribes and the constant competition among local clans for the right to collect taxes on behalf of the Ottoman authorities.

[15] French explorer Victor Guérin visited the village in 1863, and found it to be in a poor state, but with beautiful old elements as part of the houses.

[27] On 5 November 1990 at Al-Lubban ash-Sharqiya, a local villager, Ali el Khatib, aged 65 was gunned down while riding his donkey to an olive grove, and a few second later, gunfire from the same Israeli Peugeot killed Miriam Salman Rashid while she was standing outside her home.

On the basis of evidence collected in an intensive investigation, police concluded that it was an operation undertaken by members of the Kach militant organization in retaliation for Meir Kahane's murder in New York earlier that day.

According to the writers, this was part of a systematic strategy to remove all Palestinians from Area C, and the authors concluded that "an infrastructure of Jewish terror is being created in the West Bank.

[31] Police forensics officers were called in to determine whether it was arson or an electrical failure, while the PA said the fire was started by settlers in a price tag attack.

"[33] The family of Rasmia Awase found 40 olive trees they had planted two decades earlier on their plot near the settlement of Eli chopped down when they came to harvest the fruits.

[34] In February 2012 an IDF soldier from the Golani Brigade, together with two women were arrested for defacing a village home with graffiti "Mohammed is a Pig".

[35] In March 2012 the UN published a report about the take-over by Israeli settlers of water resources on the West Bank, including the spring Ein El Mukheimer near al-Lubban al-Sharqiyya, traditionally used by villagers for irrigation and domestic purposes.

[citation needed] Large parts of its western and northern sides were restored and reconstructed in the later Ottoman period as indicated by the size and style of the stones.

[citation needed] Factors behind its construction include its important location as a crossroads between central Palestine's major towns and the close proximity of a freshwater well.