The railroad operates an 85-mile (137 km) line leased from the Canadian Pacific Kansas City (CPKC).

[1] The railroad began operating on November 20, 2005 on lines leased from the Kansas City Southern Railway.

On March 31, 1986, MidSouth Rail purchased 373 miles (600 km) of track, which included this line, from the Illinois Central Gulf.

On January 1, 1994, the Kansas City Southern Railway bought out Midsouth Rail.

[3] The railroad interchanges with the KCSR at Artesia, CSX Transportation in Brookwood, and the Norfolk Southern Railway in Tuscaloosa.