The Mississippian Railway (reporting mark MSRW) is a short line railroad operating from Amory to Fulton, Mississippi.

By 1968 the bentonite deposits near Smithville had been depleted and the plant closed, however several industries had moved to Fulton and continued to provide traffic for the railroad.

Local business owners and public officials teamed up with the Appalachian Regional Commission to save the railroad.

They successfully lobbied the Interstate Commerce Commission to withhold the sale of the line until the funds to purchase it could be found.

[citation needed] The railroad previously operated a pair of 1920 Baldwin 2-8-0s until 1967 when diesels replaced them.