The highway travels from SR 189 southeast of Elba north to U.S. Route 331 (US 331) and SR 9 south of Brantley.

From here, the highway heads north-northwest through farmland until it intersects US 84 (internally designated as SR 12); the two highways share a brief concurrency.

SR 141 continues north past this intersection and meets SR 166 at its western terminus in Danleys Crossroads.

Past this intersection, SR 141 heads north through a rural area before turning northwest and entering Crenshaw County.

The highway runs northwest from here to its terminus, an intersection with US 331 (internally designated as SR 9) south of Brantley.