State Route 163 (SR 163) is a 11.104-mile (17.870 km) state highway that serves as a north–south connection between Mobile and Theodore through Mobile County.

SR 163 intersects SR 193 at its southern terminus and US 90 at its northern terminus.

[2] From its terminus, SR 163 travels in a northeasterly direction on Hollingers Island and passes the Mobile Downtown Airport en route to its intersection with I-10.

[3] From its junction with I-10, SR 163 continues in a northerly direction to its northern terminus at Government Street in central Mobile.

[4] The entire route is in Mobile County.