SR 25 traverses one of the higher peaks in the Birmingham area, Double Oak Mountain, connecting the Coosa and Cahaba River valleys.

The roadway was constructed between 1914 and 1921 with support from Buffalo Rock founder Sidney Word Lee, who owned a 3,000-acre camp in Calcis.

There is also a railroad line that travels parallel with SR 25 between Vincent and Leeds that tunnels through Double Oak Mountain below the highway.

This road is off limits to heavy trucks except for local deliveries due to a large number of sharp curves, blind entrances and exits, and a narrow, elevated roadway.

The exclusive and private Shoal Creek Golf and Country Club, home of the 1984 and 1990 PGA Championships is located on Shelby County Route 41 not far from its intersection with SR 25.