U.S. Route 78 in Alabama

East of Birmingham to the Georgia state line, US 78 has been replaced as a major through-route by I-20.

US 78 leaves its concurrency with I-22 at exit 85 and joins SR 5 (Bankhead Highway) near Graysville.

US 78 parallels the railroads, including Amtrak's Crescent service; Amtrak trains stop at Birmingham station near 1st Avenue N and 19th Street N. US 78 turns south along 24th Street and then turns east along another one-way pair.

The split ends at 36th Street S. Starting in Irondale, US 78 begins to have numerous direct or indirect encounters with I-20.

US 78 enters I-20 at Cooks Springs and leaves the freeway at the next exit near Pell City.

After leaving Pell City and entering Riverside, US 78 finds itself paralleling the Coosa River.

After crossing the river, the route enters Lincoln and eventually intersects with SR 77 near downtown.

[10] Before the early 1950s, US 78 east followed a two-lane road through the heart of Graysville (Main Street) and then shared the current four-lane road until Adamsville when it became Main Street once again and then became Forestdale Boulevard near the present interchange of US 78 and Minor Parkway.

[11] In 1953, US 78 was rerouted south to bypass Anniston; part of the old alignment became SR 202.