State Route 291 (SR 291) is a 0.89-mile-long (1.43 km) route that serves as a connection between SR 759 and US 278/US 431 in the eastern section of Gadsden in Etowah County.

It was originally proposed as an extension of SR 759.

[citation needed] The southern terminus of SR 291 is located at the eastern terminus of SR 759.

[2] From this point, the route generally travels in a northerly direction before terminating at US 278/US 431 in Gadsden.

[3] The entire route is in Gadsden, Etowah County.