It is a spur route that runs for 4.54 miles (7.31 km) between the cities of Attalla and Gadsden in Etowah County.

[3] From this point, the route travels in an easterly direction across a marshy area prior to reaching its first exit at Black Creek Parkway, a diamond interchange.

[4][5] From the Black Creek exit, I-759 continues in its easterly direction and crosses the Coosa River along a causeway and short bridge prior to reaching US 411.

[6] At the US 411 interchange, the I-759 designation ends, but the route continues as SR 759 in spanning the Coosa River.

[9] In March 2021, the Alabama Department of Transportation (ALDOT) announced that they had authorized a $2 million to initiate the engineering design for the extension.