State Route 301 (SR 301) is a north–south route located entirely in Calhoun County in east-central Alabama.

SR 301 is a former alignment of U.S. Route 431 (US 431) in the Oxford area.

[2] The SR 301 designation was established in February 2016 when US 431 was re-routed onto I-20 after the completion of the Anniston Eastern Bypass.

US 431 followed a concurrency with US 78, but this short link road between the two U.S.

The entire route is in DeArmanville, Calhoun County.