Alafia landolphioides grows as a liana up to 20 metres (66 ft) long, with a stem diameter of up to 2.5 centimetres (1 in).

Its fragrant flowers feature a white corolla, dark red at the throat.

The fruit is dark brown with paired cylindrical follicles, each up to 45 centimetres (18 in) in diameter.

Its habitat is forest and savanna, from sea-level to 1,000 metres (3,300 ft) altitude.

Local medicinal uses include as a treatment for rheumatism.