Among its present and past faculty, researchers, and alumni there are two Nobel Prize winners, two Lasker Award winners, two MacArthur Fellowship recipients, one Gairdner Foundation International Award winner, former Surgeon General of the United States Army, former Surgeon General of the United States Air Force, several presidents and CEOs of major academic hospitals, as well as an early president and co-founder of the American Medical Association.
AMC is attributed as the site where David S. Sheridan perfected the modern-day disposable catheter, among other major discoveries and innovations.
There are multiple courses of study at the college with tracks that end in an MD degree, as well as a Graduate Studies program with the following departments: In addition to the traditional medical school application process, AMC reserves up to 50 places in its first-year class for participants in combined-degree programs.
The AMC Physician Assistant Program was established in 1972, in collaboration with Hudson Valley Community College.
In October 1958, the college, alongside the medical center, started a public radio station, WAMC.