Bosomtwi-Sam started the Bosumtwi - Sam & Associates Law Firm in Takoradi in the Western Region.
[3] He served as Chief whip of the NDC in the first parliament of the fourth republic of Ghana.
Albert Bosomtwi-Sam was elected during the 1992 Ghanaian parliamentary election as member of the first parliament of the fourth republic of Ghana on the ticket of the National Democratic Congress.
Bosomtwi-Sam contested the seat again in 1996 Ghanaian general election, but lost against Papa Owusu-Ankomah of the New Patriotic Party (NPP).
Owusu-Ankomah polled 28,802 votes, representing 53.80% of the share over his opponents Albert Bosomtwi-Sam,who polled 14,990 votes representing 28.00% of the share, and Anthony Ackah of the People's National Convention (PNC), who polled 715 votes representing 1.30% of the share.