Together with her brother Massimo, Ferretti co-founded Aeffe S.p.A. [it], a publicly traded clothing manufacturer and distributor based in San Giovanni in Marignano,[3] in 1976.

From 1994, Ferretti extended the breadth of her company outside of Italy beginning with the acquisition of a building at 30 West 56th Street in New York City.

She also started Aeffe U.S.A., which produced and distributed clothing by Moschino, Rifat Ozbek, Jean Paul Gaultier, and Narcisco Rodriguez.

[22] Her style employs a subtle layered look, sometimes showing a hint of hand-beaded gauze which extends slightly beneath the hem of a wool dress.

Specifically the dresses are party frocks, above the knee, and enhanced by rhinestone rosettes and armour-like chain mail.

Feretti's collection includes pleated bubbled coats, toga-like minidresses and skirts, and a sparse number of gowns of soft mint green and white hues.

[26] From 2019, another capsule collection using only eco-friendly materials such as recycled cashmere and organic cotton was launched in collaboration with Livia Firth.

[33] Introduced in 2018, the manufacturing and distribution of Philosophy di Lorenzo Serafini’s childrenswear collections have been licensed to Gimel (2018–2024) and Monnalisa (2025–2032).

This business, near Prince Street, is exclusively for her Philosophy collection, the lower priced edition of Ferretti's signature line intended for younger women.

In contrast to most designers, she started boutiques for her secondary lines prior to opening a flagship store for her signature collection.