He made his Serie A debut on 10 February 2008 against Siena replacing Serginho, and scored the game's only goal with his first touch, just seventeen seconds after coming on.

Upon Ronaldinho's signing for the club, Paloschi said that, as his first-team chances were threatened, he would consider a move (preferably on loan) away from San Siro.

[6] On 27 August he moved to Parma, who'd just been relegated to Serie B in a co-ownership deal worth €2.25 million.

[8][11] Paloschi immediately left for Chievo in an initial temporary deal, with an option to buy.

[19] On 29 January 2016, Paloschi joined Premier League club Swansea City on a three-and-a-half-year deal for a fee believed to be in the range of £8 million.

[22] On 20 June 2018, SPAL decided to turn Paloschi's loan into a permanent deal for undisclosed fee.

[24] On 19 August 2021, Serie C club Siena confirmed an agreement to sign free agent Paloschi on a contract until 2025.