With Ruebush and John W. Howe, Kieffer founded the Kieffer, Ruebush, & Company music company circa 1873, which was moved from Singers Glen to Dayton, Virginia, in 1878.
Kieffer was editor of the Musical Million and Fireside Friend periodical.
It helped link teachers and students across the country, and published many songs in its pages.
One of Kieffer's most popular song books was The Temple Star, published at Singer's Glen in 1877.
One of his most popular songs was his poem Twilight is Stealing, set to music by B. C. Unseld in 1877 and published in the Temple Star.