Opened in 1850, it forms part of the Turin–Genoa railway, and is also a junction for six other lines, to Chivasso, Piacenza, Novara, Pavia, Cavallermaggiore, Ovada and San Giuseppe di Cairo.

The station is currently managed by Rete Ferroviaria Italiana (RFI).

The station was opened on 1 January 1850, upon the inauguration of the Asti–Alessandria–Novi Ligure section of the Turin–Genoa railway.

The station is also a major interchange with the urban and suburban bus lines operated by AMAG Mobilità, and suburban bus lines operated by Arfea.

Media related to Alessandria train station at Wikimedia Commons