He has previously played in Major League Baseball (MLB) for the Los Angeles Dodgers, Boston Red Sox and New York Yankees.

In 2017, Verdugo committed to represent the Mexican national team and was later called up for the 2017 and 2023 World Baseball Classics.

[8] Verdugo also received a late season promotion to the Advanced-Class A Rancho Cucamonga Quakes of the California League[9] where he played in 23 games and hit .385.

[19] He made his MLB debut as the starting center fielder that night against the San Diego Padres and was hitless in three at-bats with 3 walks.

[28] Verdugo went on the injured list on August 6 with an oblique strain and later came down with a back injury during a rehab assignment.

[30] On February 10, 2020, the Dodgers traded Verdugo, Jeter Downs, and Connor Wong to the Boston Red Sox in exchange for Mookie Betts, David Price, and cash considerations.

[23] He also played in 11 postseason games, batting 13-for-42 (.310) as the Red Sox advanced to the American League Championship Series.

[23] At the end of the regular season, Red Sox manager Alex Cora highlighted Verdugo as a player who could improve for 2023, stating, “Yeah, he hit for average, but he can be a lot better baserunning, defensively.

"[36] On January 13, 2023, the Red Sox and Verdugo reached agreement on a one-year contract, avoiding salary arbitration.

[39] On December 5, 2023, the Red Sox traded Verdugo to the New York Yankees for Richard Fitts, Greg Weissert, and Nicholas Judice.

[40][41] After struggling to start the 2024 season and continuing to experience the skin issues and pain which had been present in his hands since 2021, Verdugo submitted to an allergy test during the All-Star break.