He was the son of Alexander Blair (1737–c.1816), a manufacturer and merchant in the Birmingham area, and brother of the writer and historian Mary Margaret Busk.
[7] Socially, he knew James Boswell and Joseph Priestley, and was connected to the Lunar Society by his acquaintance.
[11] From 1830 to 1836 he was Professor of English and Rhetoric at London University, successor to Thomas Dale who had first held the chair.
As a man of letters he did not thrive in the philological atmosphere promoted by colleagues Thomas Hewitt Key and George Long, and resigned the post.
[12] Blair was a friend of Thomas Wright Hill, and also of Samuel Carter, a Coventry lawyer and a younger man.
Specialised encyclopedias were appearing at the period, such as the Encyclopaedia, or Dictionary of Music (1825) by John Feltham Danneley.
[16] A loyal supporter of John Wilson, who wrote as "Christopher North", Blair provided both material and encouragement to his friend.