Nudelman made special contributions to the development of aircraft-mounted weapons as well as unguided rockets and anti-tank guided missiles.

In 1962, he defended his thesis in which he developed principles of construction of, and design solutions to, a new generation of autocannons.

Nudelman closely worked with Professor Leonid Linnik, head of the laboratory of optical quantum generators of the Filatov Institute of Eye Diseases and Tissue Therapy, where experimental and clinical approbation of the first laser devices of the USSR, developed at OKB-16, took place.

Nudelman worked and lived in Moscow until his death, and was buried with military honours in the Kuntsevo Cemetery.

Some weapons Nudelman designed include the NS-37, NS-23, N-37, NS-45, N-57, NS-76, NR-23, NR-30 autocannons, S-5, S-8, S-25 rockets, the 3M11 Falanga missile and its variants, the 9K112 Kobra, the Strela-1, 9K35 Strela-10, the OK-1 and OK-2 medical lasers, among others.