The mother died early, and the father and eldest daughter were engaged in raising the youngest children.

In 1880, he became part of Narodnaya Volya, conducted propaganda among students, raised funds for the party, and participated in the preparation of an attempt on the assassination of the gendarme Georgy Sudeikin.

In 1914, he returned to Russia, arrived in the Yenisei Governorate to end the term of exile, settled in the village of Kazachinskoe, then in Krasnoyarsk.

After several months as a bacteriologist in the Zemsky Union on the Western Front, he worked in Petrograd at a private bacteriological institute.

After the February Revolution of 1917, in the government of Alexander Kerensky, he held the post of director of the office in the Ministry of Agriculture (Minister Viktor Chernov).

On 13 August 1918 he was appointed manager of agriculture and state property in the Provisional Regional Government of the Urals from the Socialist Revolutionary Party.

Therefore, the coup d'état of Admiral Kolchak in Omsk led to the liquidation of the interim government of the Urals and the return of Pribylev to the activities of a bacteriologist.

[3] Two weeks before his death, already a seriously ill, bedridden old man, Pribylev underwent an attempt to be arrested by the employees of the People's Commissariat of Internal Affairs.

However, the wife Anna Pavlovna, also a former convict, lay on the floor at the front door and told the one who presented her with a warrant for her husband's arrest: "Only through my corpse!".