[2] Titus’s career spans academia, government, and the private sector, starting with roles in data science and bioinformatics at Dartmouth College.

[3] Titus served as assistant director of biotechnology at the U.S. Department of Defense[citation needed], leading modernization efforts and helping establish BioMADE.

[12] Titus's academic appointments include roles as a principal scientist at the USC Information Sciences Institute,[13] Research Faculty at the USC Iovine and Young Academy,[14] External Fellow at the International Computer Science Institute in Berkeley, CA,[15] and Affiliate Faculty at the University of New Hampshire.

[17] He has held positions on various policy and strategic committees, including the COVID-19 High-Performance Computing Consortium[18][19] and the National Science and Technology Council at the White House.

Throughout his career, Titus has served as an advisor to numerous startups and organizations, leveraging his expertise in computational product development and government strategy.