A member of the Mavrogheni family, his father, Spyridon Mavrogenis Pasha, was the personal physician of the Ottoman Sultan Abdul Hamid II.

[citation needed] Sinan Kuneralp, author of "Ottoman Diplomatic and Consular Personnel in the United States of America, 1867-1917," described him as "well-connected".

[1] When relations between Spyridon and Abdul Hamid declined, Alexandros lost his ambassadorial position.

[citation needed] However, he was an extremely nervous and timid man and because of the situation with the quarreling political factions on the island, which left no room for wise administration.

[citation needed] He founded the Mavrogenios Professional School of Malagari and also ordered built the marble fountain of the monastery of Zoodohos Pigi.